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Support Glutathione Recycling with Micronutrients Making and recycling glutathione requires several vitamins and minerals: Vitamin C helps regenerate oxidized glutathione More in comments below Continuation Vitamin E works together with glutathione in antioxidant defense B vitamins (especially B6, B12, and folate) support methylation and amino acid metabolism linked to glutathione synthesis Selenium is a cofactor for glutathione peroxidase, a key enzyme Magnesium and zinc support multiple antioxidant enzymes Avoid What Depletes It To preserve your glutathione system: Limit excess alcohol Avoid smoking and secondhand smoke Minimize exposure to heavy metals and pollutants where possible Reduce chronic stress Get adequate sleep, when antioxidant systems are restored Bottom Line For most healthy people, you dont need a supplement to support glutathione